Labastida, J.A., Fernandez, R.F., Chu, T., Puleo, N., Shishikura, M., Wolfgang, M.J., Scafidi, J., & Scafidi, S. (2026). Loss of Fatty Acid Oxidation by Neural Stem and Progenitor Cells Increases Proliferation but Does Not Improve Long-Term Neurogenesis After Mild Traumatic Brain Injury. ASN Neuro, 18(1). https://doi.org/10.1080/17590914.2025.2610198
2025
Fernandez, R.F., Fallatah, W., Ji, Y., Jones, J.W., Johnson, C.C., Tressler, Glunde, K., Ali, R. Moser, A. B., Wolfgang, M.J., Scafidi, S., & Scafidi, J. (2025). Dysregulated hippocampal fatty acid metabolism following intermittent hypoxemia–induced neonatal brain injury is rescued by treatment with acetate. Nature Communications, 17, Article 840. https://www.nature.com/articles/s41467-025-67542-6
Fernandez, R.F., Weglarczyk, P., Zokaei, S., Huguenin, S., Scafidi, J., Ellis, J.M., & Scafidi, S. (2025). Aging Effects on Lipid Metabolism in Response to Traumatic Brain Injury. Journal of Neurochemistry. https://onlinelibrary.wiley.com/doi/pdf/10.1111/jnc.70227
Lammert, D.B., Fernandez, R. F., Liu, X., Chen, J., Koehler, R. C., Scafidi, S., et al. (2025). Proteomic analysis of hippocampus reveals metabolic reprogramming in a piglet model of mild hypoxic ischemic encephalopathy. PLOS ONE, 20(4), e0320869. https://doi.org/10.1371/journal.pone.0320869
Scafidi, S., Xu, S., Jernberg, J. N., Chu, T., Fiskum, G., & McKenna, M. C. (2025). Longitudinal brain structural, neurochemical, and behavioral changes following traumatic brain injury in immature rat brain with acetyl-L-carnitine treatment. Neurochemical Research, 50(4), 256–269. https://doi.org/10.1007/s11064-025-XXXXX
Choi, J., Smith, D. M., Scafidi, S., Riddle, R. C., & Wolfgang, M. J. (2024). Carnitine palmitoyltransferase 1 facilitates fatty acid oxidation in a non-cell-autonomous manner. Cell Reports, 43(12), Article XXXX. https://doi.org/10.1016/j.celrep.2024.XXXXX
2024
Yao, M., Wei, Z., Nielsen, J. S., Ouyang, Y., Kakazu, A., Wang, H., et al. (2024). Senolytic therapy preserves blood–brain barrier integrity and promotes microglia homeostasis in a tauopathy model. Neurobiology of Disease, 202, 106711. https://doi.org/10.1016/j.nbd.2024.106711
Choi, J., Smith, D. M., Lee, Y. J., Cai, D., Hossain, M. J., O’Connor, T. J., et al. (2024). Etomoxir repurposed as a promiscuous fatty acid mimetic chemoproteomic probe. iScience, 27(9), Article XXXX. https://doi.org/10.1016/j.isci.2024.XXXXX
Rae, C. D., Baur, J. A., Borges, K., Dienel, G., Díaz-García, C. M., Douglass, S. R., et al. (2024). Brain energy metabolism: A roadmap for future research. Journal of Neurochemistry, 168(5), 910–954. https://doi.org/10.1111/jnc.15888
Khoury, E. S., Patel, R. V., O’Ferrall, C., Fowler, A., Sah, N., Sharma, A., et al. (2024). Dendrimer nanotherapy targeting glial dysfunction improves inflammation and neurobehavioral phenotype in an adult female Mecp2-heterozygous mouse model. Journal of Neurochemistry, 168(5), 841–854. https://doi.org/10.1111/jnc.15872
2023
Martinez-Garza, U., Choi, J., Scafidi, S., & Wolfgang, M. J. (2023). Proteomics identifies the developmental regulation of HKDC1 in liver of pigs and mice. American Journal of Physiology–Regulatory, Integrative and Comparative Physiology, 325(2), RXXX–RXXX. https://doi.org/10.1152/ajpregu.XXXXX
Yelton, S. E. G., Williams, M. A., Young, M., Fields, J., Pearl, M. S., Casella, J. F., et al. (2023). Perioperative management of pediatric patients with moyamoya arteriopathy. Journal of Pediatric Intensive Care, 12(3), 159–166. https://doi.org/10.1055/s-0042-1751034
Bowman, C. E., Scafidi, J., & Scafidi, S. (2019). Metabolic perturbations after pediatric traumatic brain injury: It’s not just about glucose. Experimental Neurology, 316, 74–84. https://doi.org/10.1016/j.expneurol.2019.04.002
2022
Scafidi, S., Jernberg, J. N., Fiskum, G., & McKenna, M. C. (2022). Metabolism of exogenous [2,4-¹³C] β-hydroxybutyrate following traumatic brain injury in immature rats: An ex vivo NMR study. Metabolites, 12(8), 710. https://doi.org/10.3390/metabo12080710
Wolfgang, M. J., Choi, J., & Scafidi, S. (2021). Functional loss of ketogenesis in odontocete cetaceans. Journal of Experimental Biology, 224(20), jeb243062. https://doi.org/10.1242/jeb.243062
2021
Shi, A. C., Rohlwink, U., Scafidi, S., & Kannan, S. (2021). Microglial metabolism after pediatric traumatic brain injury: Overlooked bystanders or active participants? Frontiers in Neurology, 11, 626999. https://doi.org/10.3389/fneur.2020.626999
Gottschalk, A., Scafidi, S., & Toung, T. J. K. (2021). Brain water as a function of age and weight in normal rats. PLOS ONE, 16(9), e0249384. https://doi.org/10.1371/journal.pone.0249384
Wolfgang, M. J., Choi, J., & Scafidi, S. (2021). Functional loss of ketogenesis in odontocete cetaceans. Journal of Experimental Biology, 224(20), jeb243062. https://doi.org/10.1242/jeb.243062
2020
White, C. J., Lee, J., Choi, J., Chu, T., Scafidi, S., & Wolfgang, M. J. (2020). Determining the bioenergetic capacity for fatty acid oxidation in the mammalian nervous system. Molecular and Cellular Biology, 40(10), e00037-20. https://doi.org/10.1128/MCB.00037-20
Hansen, D., Hidalgo, J., Cohen, A., Mukherjee, D., & Scafidi, S. (2020). Evaluation and management of symptomatic vasospasm following endoscopic endonasal resection of pediatric adamantinomatous craniopharyngioma. Case Reports in Pediatrics, 2020, 8822874. https://doi.org/10.1155/2020/8822874
2019
Bowman, C. E., Alpergin, E. S. S., Cavagnini, K., Smith, D. M., Scafidi, S., et al. (2019). Maternal lipid metabolism directs fetal liver programming following nutrient stress. Cell Reports, 29(5), 1299–1310.e3. https://doi.org/10.1016/j.celrep.2019.09.067
Klimova, N., Long, A., Scafidi, S., & Kristian, T. (2019). Interplay between NAD⁺ and acetyl-CoA metabolism in ischemia-induced mitochondrial pathophysiology. Biochimica et Biophysica Acta – Molecular Basis of Disease, 1865(8), 2069–2085. https://doi.org/10.1016/j.bbadis.2019.04.010
Bowman, C. E., Scafidi, J., & Scafidi, S. (2019). Metabolic perturbations after pediatric traumatic brain injury: It’s not just about glucose. Experimental Neurology, 316, 74–84. https://doi.org/10.1016/j.expneurol.2019.04.002
Jackson, E. M., Costabile, P. M., Tekes, A., Steffen, K. M., Ahn, E. S., Scafidi, S., et al. (2018). Use of telemedicine during interhospital transport of children with operative intracranial hemorrhage. Pediatric Critical Care Medicine, 19(11), 1033–1038. https://doi.org/10.1097/PCC.0000000000001708
2018
Kim, S. P., Li, Z., Zoch, M. L., Frey, J. L., Bowman, C. E., Kushwaha, P., et al. (2017). Fatty acid oxidation by the osteoblast is required for normal bone acquisition in a sex- and diet-dependent manner. JCI Insight, 2(16), e92704. https://doi.org/10.1172/jci.insight.92704
Scafidi, S., Jernberg, J. N., Bowman, C. E., & Wolfgang, M. J. (2017). Developmental regulation and localization of carnitine palmitoyltransferases in rat brain. Journal of Neurochemistry, 142(3), 407–419. https://doi.org/10.1111/jnc.14054
Lee, J., Choi, J., Alpergin, E. S. S., Zhao, L., Hartung, T., Scafidi, S., et al. (2017). Loss of hepatic mitochondrial long-chain fatty acid oxidation confers resistance to diet-induced obesity and glucose intolerance. Cell Reports, 20(3), 655–667. https://doi.org/10.1016/j.celrep.2017.06.080
2017
, S., Bowman, C., Poudel, M., & Wolfgang, M. (2017). Alterations in metabolic pathways following experimental traumatic brain injury in immature rat. Journal of Neurotrauma, 34(13), A132–A133. https://doi.org/10.1089/neu.2017.5341
Lee, J., Choi, J., Scafidi, S., & Wolfgang, M. J. (2016). Hepatic fatty acid oxidation restrains systemic catabolism during starvation. Cell Reports, 16(1), 201–212. https://doi.org/10.1016/j.celrep.2016.05.030
Lee, J., Choi, J., Aja, S., Scafidi, S., & Wolfgang, M. J. (2016). Loss of adipose fatty acid oxidation does not potentiate obesity at thermoneutrality. Cell Reports, 14(6), 1308–1316. https://doi.org/10.1016/j.celrep.2016.02.036
McKenna, M. C., Scafidi, S., & Robertson, C. L. (2015). Metabolic alterations in developing brain after injury: Knowns and unknowns. Neurochemical Research, 40(12), 2527–2543. https://doi.org/10.1007/s11064-015-1639-2
Bartnik-Olson, B. L., Harris, N. G., Shijo, K., Sutton, R. L., Alberto, I. B., & Scafidi, S., et al. (2015). Frontiers in mini review article. Transcellular Cycles Underlying Neurotransmission, 76, 1–15. https://doi.org/10.1016/j.brainres.2015.01.023
Scafidi, S., Jernberg, J., Bowman, C., & Wolfgang, M. J. (2015). Astrocytes increase fatty acid oxidation following traumatic brain injury in the developing brain. Glia, 63, E180. https://doi.org/10.1002/glia.22845
Spaeder, M. C., Custer, J. W., Miles, A. H., Ngo, L., Morin, N. P., & Scafidi, S., et al. (2015). A multicenter outcomes analysis of children with severe rhino/enteroviral respiratory infection. Pediatric Critical Care Medicine, 16(2), 119–123. https://doi.org/10.1097/PCC.0000000000000346
2014
Kurz, J. E., Edwards, J., Scafidi, S., Gallo, V., & Scafidi, J. (2014). Intranasal epidermal growth factor treatment ameliorates hippocampal dysfunction in a mouse model of premature brain injury. Annals of Neurology, 76, S230–S231. https://doi.org/10.1002/ana.24234
Scafidi, J., Hammond, T. R., Scafidi, S., Ritter, J., Jablonska, B., Roncal, M., et al. (2014). Intranasal epidermal growth factor treatment rescues neonatal brain injury. Nature, 506(7487), 230–234. https://doi.org/10.1038/nature12914
Schousboe, A., Scafidi, S., Bak, L. K., Waagepetersen, H. S., & McKenna, M. C. (2014). Glutamate metabolism in the brain focusing on astrocytes. Advances in Neurobiology, 11, 13–30. https://doi.org/10.1007/978-3-319-08894-5_2
Stadick, S., Su, X., Fiskum, G., McKenna, M. C., & Scafidi, S. (2014). Acetyl-L-carnitine improves metabolic dysfunction and behavioral outcome after traumatic brain injury in immature rat. Journal of Neurotrauma, 31(12), A63–A63. https://doi.org/10.1089/neu.2014.3452
Robertson, C. L., Saraswati, M., Scafidi, S., Fiskum, G., Casey, P., & McKenna, M. C. (2013). Cerebral glucose metabolism in an immature rat model of pediatric traumatic brain injury. Journal of Neurotrauma, 30(24), 2066–2072. https://doi.org/10.1089/neu.2012.2773
2013
Spaeder, M. C., Custer, J. W., Bembea, M. M., Aganga, D. O., Song, X., & Scafidi, S., et al. (2013). A multicenter outcomes analysis of children with severe viral respiratory infection due to human metapneumovirus. Pediatric Critical Care Medicine, 14(3), 268–272. https://doi.org/10.1097/PCC.0b013e31827fa28b
McKenna, M. C., Waddell, J., Diamond, M., Kelly, T., Demers, D., Shi, D., & Scafidi, S. (2013). Acetyl-L-carnitine protects mitochondrial enzymes and improves long-term outcome after neonatal hypoxic-ischemic brain injury. Journal of Neuroscience Research, 91(8), 1105–1106. https://doi.org/10.1002/jnr.23372
Scafidi, S., McKenna, M. C., & Fiskum, G. (2013). Delayed glucose metabolism and increased utilization of β-hydroxybutyrate following traumatic brain injury in immature rats. Journal of Neuroscience Research, 91(8), 1093–1104. https://doi.org/10.1002/jnr.23296
Shi, D., Xu, S., Waddell, J., Scafidi, S., Roys, S., Gullapalli, R. P., & McKenna, M. C. (2012). Longitudinal in vivo developmental changes of metabolites in the hippocampus of Fmr1 knockout mice. Journal of Neurochemistry, 123(6), 971–981. https://doi.org/10.1111/jnc.12048
Scafidi, S., Xu, S., Kabadi, S. V., Waddell, J. L., Gullapalli, R., Fadan, A., et al. (2012). Acetyl-L-carnitine (ALCAR) provides long-term neuroprotection after traumatic brain injury in immature rats. Annals of Neurology, 72, S147. nhttps://doi.org/10.1002/ana.23619
2011
McKenna, M. C., Scafidi, S., Racz, J., Shi, D., & Fiskum, G. (2011). Neuroprotective effects of acetyl-L-carnitine (ALCAR) after traumatic brain injury in young rats. Journal of Neurochemistry, 118, 227–228. https://doi.org/10.1111/j.1471-4159.2011.07264.x
Scafidi, S., Racz, J., Hazelton, J., McKenna, M. C., & Fiskum, G. (2011). Neuroprotection by acetyl-L-carnitine after traumatic injury to the immature rat brain. Developmental Neuroscience, 32(5-6), 480–487. https://doi.org/10.1159/000330911
Robertson, C., Scafidi, S., Saraswati, M., & McKenna, M. (2011). Determination of metabolic alterations after traumatic brain injury in immature rats using proton spectroscopy. Journal of Neurotrauma, 28(6), A53. https://doi.org/10.1089/neu.2010.1579
2010
Scafidi, S., Fiskum, G., Lindauer, S. L., Bamford, P., Shi, D., Hopkins, I., et al. (2010). Metabolism of acetyl-L-carnitine for energy and neurotransmitter synthesis in the immature rat brain. Journal of Neurochemistry, 114(3), 820–831. https://doi.org/10.1111/j.1471-4159.2010.06722.x
2009
Robertson, C. L., Scafidi, S., McKenna, M. C., & Fiskum, G. (2009). Mitochondrial mechanisms of cell death and neuroprotection in pediatric ischemic and traumatic brain injury. Experimental Neurology, 218(2), 371–380. https://doi.org/10.1016/j.expneurol.2009.03.024
Scafidi, S., Racz, J., Bamford, P., Shi, D., Fiskum, G., & McKenna, M. C. (2009). Oxidative neuronal and astrocytic metabolism of beta-hydroxybutyrate following traumatic brain injury in young rats. Journal of Neurotrauma, 26(8), A82. https://doi.org/10.1089/neu.2009.0968
Scafidi, S., O’Brien, J., Hopkins, I., Robertson, C., Fiskum, G., & McKenna, M. C. (2009). Delayed cerebral oxidative glucose metabolism after traumatic brain injury in young rats. Journal of Neurochemistry, 109, 189–197. https://doi.org/10.1111/j.1471-4159.2009.05908.x
Scafidi, S., Racz, J., Bamford, P., Shi, D., Fiskum, G., & McKenna, M. C. (2009). Metabolism of 3-beta-hydroxybutyrate in brain after traumatic brain injury in young rats. Journal of Neurochemistry, 108, 156. https://doi.org/10.1111/j.1471-4159.2009.05822.x
2007–2002 (selected)
McKenna, M. C., Lindauer, S. L., Fiskum, G., Bamford, P., Scafidi, S., Hopkins, I. B., et al. (2007). Metabolism of [2-C-13] acetyl-L-carnitine in 21-day-old rat brain for energy and neurotransmitter synthesis. Journal of Neurochemistry, 102, 116–117. https://doi.org/10.1111/j.1471-4159.2007.04528.x
Scafidi, S., O’Brien, J., Robertson, C., Saraswati, M., Fiskum, G., & McKenna, M. C. (2007). Delayed cerebral metabolism of [1,6-13C] glucose after traumatic brain injury in immature rat. Journal of Neurotrauma, 24(7), 1266. https://doi.org/10.1089/neu.2007.0302
Scafidi, S., Douglas, R. M., Farahani, R., Banasiak, K. J., & Haddad, G. G. (2007). Prostaglandin transporter expression in mouse brain during development and in response to hypoxia. Neuroscience, 146(3), 1150–1157. https://doi.org/10.1016/j.neuroscience.2007.02.048
Scafidi, S., McKenna, M., Robertson, C., Saraswati, M., & Fiskum, G. (2006). H-1 and C-13 NMR studies of cerebral glucose metabolism following traumatic brain injury in immature rats. Journal of Neurotrauma, 23(6), 1036. https://doi.org/10.1089/neu.2006.23.1036
Scafidi, S., Haddad, G. G., & Banasiak, K. J. (2005). Brain prostaglandin transporter expression during development and hypoxia. Pediatric Critical Care Medicine, 6(1), 116. https://doi.org/10.1097/01.PCC.0000154397.03582.7A
Scafidi, S., Stock, A. C., & Ozuah, P. O. (2003). Comparison of peripheral-venous to central-venous oxygen saturation. Pediatric Research, 53(4), 50A. https://doi.org/10.1203/01.PDR.0000060900.24245.D7
Scafidi, S., Stock, A. C., & Ozuah, P. O. (2003). Comparing peripheral-venous to central-venous oxygen saturation. Journal of Investigative Medicine, 51, S428–S428. https://doi.org/10.2310/JIM.0b013e3180112b6b
